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Endogenous opioids and post-ictal increase in seizure threshold in Mongolian gerbils

✍ Scribed by Hans-Hasso Frey

Book ID: 103932020
Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 422 KB
Volume: 1
Category: Article
ISSN: 0920-1211
DOI: 10.1016/0920-1211(87)90017-9

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✦ Synopsis

In gerbils, the convulsive thresholds both for electroconvulsions and for pentetrazole-induced convulsions were increased when determined 15 min after a convulsion elicited by an air blast to the back of the animals. Contrary to a recently offered hypothesis, this sign of post-ictal depression could not be reversed by pretreatment with the morphine antagonists naloxone and naltrexone. This result speaks against a mediation of post-ictal depression by endogenous opioids.

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