✦ LIBER ✦
Endogenous opioid systems and the growth of oligodendrocyte progenitors: Paradoxical increases in oligodendrogenesis as an indirect mechanism of opioid action
✍ Scribed by Dr. Kurt F. Hauser; Julie A. Gurwell; Dr. Narayan R. Bhat
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 693 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0894-1491
No coin nor oath required. For personal study only.
✦ Synopsis
Endogenous opioids inhibit nervous system development by inhibiting the proliferation of certain neuronal and glial progenitors. To determine whether opioids affect the growth of preoligodendrocytes, the effects of the endogenous opioid [Met5]enkephalin were examined in preoligodendrocytes in primary mixed-glial and preoligodendrocyte-enriched (>98% pure) cultures. Proliferating preoligodendrocytes in mixed-