Endogenous opioid immunoreactivity in rat spinal cord following traumatic injury
β Scribed by Dr Alan I. Faden; Christopher J. Molioneaux; John G. Rosenberger; Thomas P. Jacobs; Brain M. Cox
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 550 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0364-5134
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Spinal cord samples from rats subjected to three different levels of impact trauma (25, 50, 100 g-cm) were examined for immunoreactive thromboxane B2 and 6-sulfidopeptide-containing leukotrienes, using specific radioimmunoassays. Trauma resulted in pronounced increases in thromboxane levels as early
Spinal cord injury is accompanied by an initial inflammatory reaction followed by secondary injury that is caused, in part, by apoptosis. Recruitment of leukocytes from the blood compartment to the site of inflammation in the injured spinal cord has been attributed to locally generated chemotactic a
The reaction of oligodendrocytes in response to traumatic injury of the CNS are poorly understood. In the present report we studied changes in the expression of a major constituent of CNS myelin, myelin basic protein (MBP), by immunohistochemistry and in situ hybridization from 6 h up to 2 weeks fol
## Abstract The posttraumatic inflammatory reaction contributes to progressive tissue damage after spinal cord injury (SCI). Annexins, a family of structurally related calciumβ and phospholipidβbinding proteins, have potent antiβinflammatory effects by inhibiting the activity of phospholipase A~2~