Endogenous Inflammatory Molecules Engage Toll-Like Receptors in Cardiovascular Disease
β Scribed by Ionita, Mihaela G.; Arslan, Fatih; de Kleijn, Dominique P.V.; Pasterkamp, Gerard
- Book ID
- 121746188
- Publisher
- S. Karger AG
- Year
- 2010
- Tongue
- English
- Weight
- 340 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1662-811X
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Toll-like receptors (TLRs) are pattern recognition receptors that recognize pathogen-associated molecular patterns and signal through adaptor molecules, myeloid differentiation factor 88 (MyD88), Toll/IL-1 receptor domain containing adaptor protein (TIRAP), Toll/IL-1 receptor domain containing adapt
Differential alteration of Toll-like receptor (TLR) expression in inflammatory bowel disease (IBD) was first described 10 years ago. Since then, studies from many groups have led to the current concept that TLRs represent key mediators of innate host defense in the intestine, involved in maintaining