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Endogenous glutathione and catalase protect cultured rat astrocytes from the iron-mediated toxicity of hydrogen peroxide

✍ Scribed by Jeff R Liddell; Stephen R Robinson; Ralf Dringen


Book ID
116766733
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
85 KB
Volume
364
Category
Article
ISSN
0304-3940

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πŸ“œ SIMILAR VOLUMES


Glutathione peroxidase 1 and glutathione
✍ Jeff R. Liddell; Hans H. Hoepken; Peter J. Crack; Stephen R. Robinson; Ralf Drin πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 278 KB

## Abstract The enzyme glutathione peroxidase 1 (GPx1) is involved in the cellular detoxification of peroxides. To test for the consequences of GPx deficiency in astrocytes, astrocyte‐rich primary cultures from wild‐type and GPx1‐deficient [GPx1(–/–)] mice were exposed to H~2~O~2~. In GPx1(–/–) ast