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Endogenous and background DNA adducts by methylating and 2-hydroxyethylating agents

✍ Scribed by Chunyan Zhao; Margarita Tyndyk; Ingvar Eide; Kari Hemminki

Book ID: 114072476
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 142 KB
Volume: 424
Category: Article
ISSN: 0027-5107
DOI: 10.1016/s0027-5107(99)00013-5

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## Abstract Endogenous carcinogens arising from normal metabolism are known to cause modifications to DNA by reacting with bases to form adducts. Malondialdehyde is a well characterized endogenous carcinogen that forms an adduct with 2′‐deoxyguanosine. This adduct has been detected in rat and human