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“Endogenous adjuvant” activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60

✍ Scribed by Kindra M. Kelly; Haoyang Zhuang; Dina C. Nacionales; Philip O. Scumpia; Robert Lyons; Jun Akaogi; Pui Lee; Bryan Williams; Masahiro Yamamoto; Shizuo Akira; Minoru Satoh; Westley H. Reeves

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 253 KB
Volume: 54
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.21819

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In vivo adjuvant activity of the RNA component of the Sm/RNP lupus autoantigen

✍ Kindra M. Kelly-Scumpia; Dina C. Nacionales; Philip O. Scumpia; Jason S. Weinste 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB

## Abstract ## Objective Many lupus autoantigens contain small, highly structured RNAs, and studies have shown that the RNA components of lupus autoantigens activate production of type I interferon by dendritic cells (DCs) in vitro via the Toll‐like receptor (TLR)–myeloid differentiation factor 88