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Endodermal sinus tumors in the head and neck region

✍ Scribed by Kusumakumari, P.; Geetha, N.; Chellam, V. G.; Nair, M. Krishnan

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 144 KB
Volume: 29
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(199710)29:4<303::aid-mpo12>3.0.co;2-b

No coin nor oath required. For personal study only.

✦ Synopsis

Extragonadal germ cell tumors of the head and neck region account for only 5% of all benign and malignant germ cell tumors. Endodermal sinus tumors (EST) of the head and neck region are rare. We report three patients with EST of head and neck region over a period of 10 years; the primary sites of tumor were orbit, maxillofacial region and retroauricular region. Histopathological examination revealed malignant teratoma with predominant endodermal sinus pattern in two, and pure EST in one patient. Serum alpha fetoprotein (AFP) was elevated in all three patients. Two patients had initial surgery but did not receive adjuvant chemotherapy, as the parents refused it. Partial remission was achieved in the other patient who received chemotherapy (cisplatin, bleomycin and vinblastin) and the patient died of infection after four courses of chemotherapy.

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