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Endocytosis of the Mu Opioid Receptor Reduces Tolerance and a Cellular Hallmark of Opiate Withdrawal

✍ Scribed by Andrew K Finn; Jennifer L Whistler


Book ID
117607970
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
426 KB
Volume
32
Category
Article
ISSN
0896-6273

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Numerous reports support evidence that dopaminergic mesolimbic pathways interact with opioid systems to influence the reinforcing properties of cocaine. Withdrawal from chronic administration of cocaine in rats causes an upregulation of mesocorticolimbic mu-opioid receptors during early stages, but