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Endocytosis and binding of asialoorosomucoid by hepatocytes from rats with jejunoileal bypass

✍ Scribed by Nathalie Serbource-Goguel/Seta; Béatrice Borel; Michèle Dodeur; Pierre Scarmato; Benoit Bourel; Jeanne Feger; Dr. Geneviève Durand

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
437 KB
Volume
5
Category
Article
ISSN
0270-9139

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✦ Synopsis

Rats with jejunoileal bypass were used to study the biological activity of the hepatic binding protein. Hepatocytes were prepared 11 weeks after surgical procedure, and presence of asialoorosomucoid in serum has been determined.

Compared to control rat hepatocytes, endocytosis of [3H]asialoorosomucoid by bypassed rat hepatocytes was decreased by about 60%. This was due to a decreased number of total and surface receptors. In most sera, an accumulation of asialoorosomucoid was found. A reduction of protein synthesis or turnover could be considered.

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Studies were conducted to explore the regulation of retinol-binding protein (RBP) metabolism in cultured primary hepatocytes from retinol-deficient rats. Newly isolated hepatocytes from retinol-deficient rats contained elevated levels (3.4-fold) of RBP, compared to hepatocytes from normal (retinol-a