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Endocytic prolactin routes to the secretory pathway in lactating mammary epithelial cells

✍ Scribed by Touria Seddiki; Serge Delpal; Alain Aubourg; Georges Durand; Michèle Ollivier-Bousquet

Book ID: 114191841
Publisher: Portland Press
Year: 2002
Tongue: English
Weight: 771 KB
Volume: 94
Category: Article
ISSN: 0248-4900
DOI: 10.1016/s0248-4900(02)01188-7

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In mammary epithelial cells (MECs), prolactin-induced signaling and gene expression requires integrin-mediated cell adhesion to basement membrane (BM). In the absence of proper cell–BM interactions, for example, culturing cells on collagen-coated plastic dishes, signal propagation is substantially i