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Endocrine resistance in breast cancer: new roles for ErbB3 and ErbB4

โœ Scribed by Robert L Sutherland

Book ID
118726756
Publisher
BioMed Central
Year
2011
Tongue
English
Weight
135 KB
Volume
13
Category
Article
ISSN
1465-5411

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## Abstract Receptor tyrosine kinase activity is essential for erbB2 (HER2/__neu__) promotion of breast carcinogenesis, metastasis and therapeutic resistance. erbB2 kinase can be activated by dimerization with another erbB receptor, most of which bind ligands. Of these, the erbB2/erbB3 heterodimer