Endocrine Oncology

✍ Scribed by Elizabeth Anderson PhD, Robert B. Clarke PhD, Anthony Howell MD (auth.), Stephen P. Ethier PhD (eds.)

• Publisher: Humana Press
• Year: 2000
• Tongue: English
• Leaves: 394
• Series: Contemporary Endocrinology
• Edition: 1
• Category: Library

✦ Synopsis

Cancers of endocrine tissues are an increasingly important public health concern whose growing prevalence has made them the focus of intensive research in recent years. In Endocrine Oncology, Stephen P. Ethier and a panel of leading investigators comprehensively analyze the cellular, molecular, and endocrine factors involved in the development of cancers of the breast, prostate, endometrium, and ovary. Concentrating on defining the most important unresolved issues in the field, the authors review how steroid hormones function to regulate normal mammary gland homeostasis in humans, with particular emphasis on the roles of estrogen, progesterone, and growth factors. Also examined are the effects of steroids in prostate cancer development and treatment, the function of growth factors in endocrine neoplasia, the actions of such nonsteroid hormones as prolactin, and the role of the suppressor genes BRCA1 and BRCA2. Throughout the book, the clinical relevance of scientific findings is emphasized.
Comprehensive and up-to-date, Endocrine Oncology offers both basic and clinical
researchers not only the latest molecular and cellular findings on endocrine cancers, but also a powerful critical analysis that will prove invaluable to all endocrinologists and oncologists working in the area today.

✦ Table of Contents

Front Matter....Pages i-xi
Estrogen Receptor in Mammary Gland Physiology....Pages 1-16
Multiple Facets of Estrogen Receptor in Human Breast Cancer....Pages 17-34
Progesterone Receptors in Normal and Neoplastic Breast....Pages 35-47
Pathogenesis of Estrogen-Receptor-Positive and -Negative Breast Cancer....Pages 49-68
Regulation of EGFR and ERBB2 Expression by Estrogen Receptor in Breast Cancer....Pages 69-77
Tamoxifen and Other Antiestrogens in Prevention and Therapy of Breast Cancer....Pages 79-99
Prolactin in Human Breast Cancer Development....Pages 101-120
Human Chorionic Gonadotropin in Breast Cancer Prevention....Pages 121-136
Epidermal Growth Factor-Related Peptides in Endocrine Neoplasias....Pages 137-191
Insulin-Like Growth Factors and Endocrine Neoplasia....Pages 193-214
Insulin-Like Growth Factor Binding Proteins in Endocrine-Related Neoplasia....Pages 215-235
Fibroblast Growth Factors and Their Receptors in Breast and Prostate Cancer....Pages 237-254
Steroid Receptors in Prostate Cancer Development and Progression....Pages 255-275
Type I Family Growth Factor Receptors and Their Ligands in Prostate Cancer....Pages 277-291
Hormonal Manipulation of Prostate Cancer....Pages 293-311
Endocrinology of Epithelial Ovarian Cancer....Pages 313-324
Molecular Pathogenesis of Endometrial Cancer....Pages 325-335
Structure and Function of BRCA Genes....Pages 337-351
Role of Apoptosis and its Modulation by Bcl-2 Family Members in Breast and Prostate Cancer....Pages 353-371
Transcriptional Coactivators in Cancer....Pages 373-381
Back Matter....Pages 383-395

✦ Subjects

Oncology