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๐Ÿ“

Endocrine Disruption Modeling

โœ Scribed by James Devillers


Publisher
CRC Press
Year
2009
Tongue
English
Leaves
420
Series
QSAR in Environmental and Health Sciences
Category
Library

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โœฆ Synopsis


Endocrine Disruption Modeling provides a practical overview of the current approaches for modeling endocrine activity and the related potential adverse effects they may induce on environmental and human health. Based on the extensive research of an international panel of contributors from industry, academia, and regulatory agencies, this is the first book devoted to using computer tools to better understand and simulate the multifaceted aspects of endocrine disruption in humans and wildlife.

This up-to-date resource focuses on xenobiotics that are accidentally released into the environment with the potential to disturb the normal functioning of the endocrine system of invertebrates and vertebrates but also on the specific agro-chemistry design of chemicals that take control of insect endocrine systems. A comprehensive research reference, Endocrine Disruption Modeling provides a collection of computational strategies to model these structurally diverse chemicals. It concludes with a review of the available e-resources in the field, rounding out the bookโ€™s task-oriented approach to future EDC discovery.

โœฆ Table of Contents



Content: Mechanisms of Endocrine Disruptions --
A Structure-Activity Relationship Analysis for the Identification of Environmental Estrogens: The Categorical-SAR (cat-SAR) Approach --
Mechanism Based Modelling of ER Binding Affinity: A COREPA Implementation --
Receptor-Based 3D QSAR Analysis of Endocrine Disruptor Chemicals --
Comparative Modelling Review of Nuclear Hormone Receptor Superfamily --
Use of C NMR Spectrometric Data to Derive Predictive Models of Estrogen and Aryl Hydrocarbon Receptor Binding Activity --
Kohonen and Counter Propagation Neural Networks Employed for Modelling Endocrine Disruptors --
Endocrine Disruption Profile Analysis of Organophosphorus Pesticides from Chemometrical Tools --
Modelling the Estrogen Activity of Biphenols --
Structure-Activity Modelling of a Diverse Set of Androgen Receptor Ligands --
Population Modelling --
A Tool for Environmental Risk Assessment of Endocrine Disrupting Chemicals --
SAR and QSAR Modelling of Substituted Dibenzoy-Hydrazines for Their Mode of Action as Ecdysone Agonists --
Overview of the FDA's Endocrine Disruptor Knowledge Base (EDKB). e-Endocrine Disrupting Chemical Databases for Deriving QSAR Models --
Index.


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