✦ LIBER ✦

End-to-side neurorrhaphy

✍ Scribed by Feng Zhang; Kenneth A. Fischer

Book ID: 102513868
Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 79 KB
Volume: 22
Category: Article
ISSN: 0738-1085
DOI: 10.1002/micr.21736

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✦ Synopsis

Abstract

End‐to‐side neurorrhaphy, a possible strategy for treating nerve lesions without useable proximal nerve stumps, has been experimentally and clinically investigated. In end‐to‐side neurorrhaphy, three main elements should be considered: 1) the induction of axonal collateral sprouting in the donor nerve; 2) the ability of the collateral axons to pierce the different conjunctival layers, including the ability the donor nerve basal laminae, to reinnervate the recipient nerve; and 3) the functional plasticity and behavioral readjustment of single motoneurons that have eventually adopted new motor units. This article reviews the following areas of research and clinical investigation: animal models, axonal collateral sprouting from end‐to‐side neurorrhaphy, effect of epineurotomy and perineurotomy on axon regeneration, motor reinnervation, and clinical trials. © 2002 Wiley Liss, Inc. MICROSURGERY 22:122–127 2002

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