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Encyclopedia of Metalloproteins || QM/MM, Quantum Mechanical/Molecular Mechanical

✍ Scribed by Kretsinger, Robert H.; Uversky, Vladimir N.; Permyakov, Eugene A.


Book ID
120495154
Publisher
Springer New York
Year
2013
Weight
26 KB
Category
Article
ISBN
1461415330

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Citrate synthase forms citrate by deprotonation of acetyl-CoA followed by nucleophilic attack of this substrate on oxaloacetate, and subsequent hydrolysis. The rapid reaction rate is puzzling because of the instability of the postulated nucleophilic intermediate, the enolate of acetyl-CoA. As altern