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Encephalopathy is the dose-limiting toxicity of intravenous hepsulfam: results of a phase I trial in patients with advanced hematological malignancies

✍ Scribed by Richard A. Larson, Robert B. Geller, Linda Janisch…


Book ID
120776383
Publisher
Springer
Year
1995
Tongue
English
Weight
673 KB
Volume
36
Category
Article
ISSN
0344-5704

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Eighteen patients with advanced malignancies refractory to other forms of treatment were given dactinomycin (Act D) as continuous intravenous infusions. Their median age was 51 years (range, 36-67); their median performance status was 50 (range, 40-90) on the Karnofsky scale. Act D was administered