𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Encephalitis after inhalation of measles virus: A pathogenetic study in hamsters

✍ Scribed by Irma M. Parhad; Kenneth P. Johnson; Jerry S. Wolinsky; Peggy Swoveland

Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
809 KB
Volume
9
Category
Article
ISSN
0364-5134

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A neuroadapted strain of measles virus (HNT) was administered by inhalation to newborn hamsters. Primary replication of virus in the lung was followed by the transient appearance of virus in spleen within 7 to 9 days of inoculation. A terminal encephalitis occurred between 6 and 60 days in 31% of infecfted hamsters, and virus was recovered by explant culture of these brains. Virus could not be cultured directly from brain or tissue homogenates. At least 7% of hamsters that had survived the infection for two months had antibody to measles virus. The histopathological change in morbid animals was limited to the central nervous system (CNS) and consisted of small foci of necrosis, perivascular mononuclear cell infiltrates, intracytoplasmic and intranuclear inclusions, and vacuolated pyknotic neurons. Immunofluorescent studies disclosed measles antigen in the lungs and brain. This hamster moENl of measles encephalitis following a β€œnatural” route of inoculation appears to represent a faithful reproduction of certain CNS complications of natural measles infection in humans, i.e., measles encephalitis and subacute sclerosing panencephalitis.

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