Encapsulation of NF-κB decoy oligonucleotides within echogenic liposomes and ultrasound-triggered release

Enhanced intracellular uptake and inhibi

Enhanced intracellular uptake and inhibition of NF-κB activation by decoy oligonucleotide released from PLGA microspheres

✍ Giuseppe De Rosa; Maria Chiara Maiuri; Francesca Ungaro; Daniela De Stefano; Fab 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 317 KB

## Abstract ## Background Nuclear factor‐κB (NF‐κB) transcription factor regulates the expression of genes involved in immune response and inflammation. NF‐κB activity can be efficiently inhibited by double‐stranded oligodeoxynucleotides (ODNs). In the present study, we investigated the potential