Encapsulation of clomacran phosphate {2-chloro-9-[3-(dimethylamino)propyl]acridan phosphate} I: Effect of flowability of powder blends, lot-to-lot variability, and concentration of active ingredient on weight variation of capsules filled on an automatic capsule-filling machine
✍ Scribed by George M. Irwin; Gerald J. Dodson; Louis J. Ravin
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 443 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0022-3549
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✦ Synopsis
coefficient of variation of compressive force. However, weight variation of Formula 3 was comparable to other experiments.
Comparing experiments, hardness was not directly proportional to compressive force, indicating that these formulations require a somewhat different compression force for preparing tablets of an average hardness of 10. It is believed the variability in required compression force between different granulations of the same formula might be large enough to preclude using compressive force as a possible specification in this type of product. The reasons for shifts in required compression force have not been reported at this time nor their importance described.
All formulations were satisfactory with respect to chew and mouthfeel characteristics, and no substantial difference could be found between formulations when tasted by a small taste panel.
Moisture recovery on drying was 98-99%, and processing times varied from 105 min. for the lowest amount of added water to 120 min. for the highest amount o f added water. Whether these relatively long processing times, compared with an isopropanol process, are acceptable depends to a large degree on the kind of product being made and the required rate of production.
SUMMARY AND CONCLUSIONS
Various data on the operation of a 1-cu. ft. VTD as related to general tableting technology have been reported. The results indicate that vacuum tumble drying is a satisfactory process for some particularly common types of tablet formulations. It was found that adequate mixing could be obtained and that the short processing time coupled with good yields were other advantages. Obviously the use of such equipment on a larger scale requires the usual considerations of loading, unloading, cleaning, etc. While the authors' experience in working with the VTD on a pilot scale was highly satisfactory, other alternate methods are available. However, the convenience factor as well as other advantages listed earlier seems to indicate the VTD may often be the process of choice.