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Enantiospecific Synthesis of Trisubstituted Butyrolactone Natural Products and Their Analogs

โœ Scribed by Sibi, Mukund P.; Lu, Jianliang; Talbacka, Chelsy L.


Book ID
126158748
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
287 KB
Volume
61
Category
Article
ISSN
0022-3263

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## Abstract Enantioselective syntheses of several paraconic acids have been achieved using catalyzed asymmetric hydrogenation of ฮฒโ€keto esters with SYNPHOS^ยฎ^ as a ligand. This strategy allowed the short synthesis of biologically active (โˆ’)โ€methylenolactocin **1**, (โˆ’)โ€protolichesterinic acid **2**