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Enantiospecific synthesis of an indolizidine alkaloid, (+)-ipalbidine

✍ Scribed by Toshio Honda; Hidenori Namiki; Hiromasa Nagase; Hirotake Mizutani

Book ID: 104253381
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 179 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00563-x

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✦ Synopsis

Enantiospecific total synthesis of an indolizidine alkaloid, ipalbidine, was achieved starting from (-)-pyroglutamic acid by employing an intramolecular McMurry coupling reaction with a low-valent titanium, as a key step.

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