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Enantiospecific Synthesis of 2,5-Disubstituted Piperidine Derivatives: Synthesis of (+)-Pseudoconhydrine

✍ Scribed by Dockner, Michael ;Sasaki, N. André ;Riche, Claude ;Potier, Pierre

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
683 KB
Volume
1997
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

A novel methodology for the synthesis of any one of the four stereoisomers of a 2,5‐disubstituted piperidine in optically pure form is described, starting from readily available chiral building blocks 10 and 11 (or their antipodes). The utility of this approach is demonstrated in the total synthesis of (+)‐pseudoconhydrine hydrochloride, the structure of which was confirmed by X‐ray analysis.

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✍ Joakim Loefstedt; Helena Pettersson-Fasth; Jan-E. Baeckvall 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

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