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Enantioselectively catalyzed intramolecular cyclopropanations of unsaturated diazo carbonyl compounds

✍ Scribed by William G. Dauben; Robert T. Hendricks; Michael J. Luzzio; Howard P. Ng

Book ID
104228511
Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
366 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

A series of unsaturated a-diazo carbonyl compounds umierwent enantioselective intramolecular cyclopropanation (ee = 4-77%) when treated with an enantiomerically pure chiral copper catalyst. The nature of the diazo substrate was critical: a-diazo ketones gave the best &antioselectivities whereas a-diazo p-keto ester systems showed diminished enantioselectivities.

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