Enantioselective total synthesis of marine alkaloids, manzamine A and related compounds
โ Scribed by Masako Nakagawa
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2000
- Tongue
- English
- Weight
- 606 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-152X
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โฆ Synopsis
Abstract
A review of our studies toward the enantioselective total synthesis of ircinal A, manzamine A and related compounds is presented in detail.
๐ SIMILAR VOLUMES
Enantioselective Total Syntheses of Ircinal A and Related Manzamine Alkaloids. -The enantioselective total synthesis of ircinal A (VIII) is presented involving a novel tandem Stille coupling-[4 + 2] cycloaddition reaction and two ring-closing metathesis reactions as the key steps. Thus, Stille coup
The first total synthesis of haliclamine A (1), a macrocyclic marine alkaloid closely related to the key bisdihydropyridine intermediate 3 of the biogenetically unique manzamine family, has been efficiently achieved via stepwise inter-and intramolecular N-alkylations of 3-alkylpyridine derivatives 2