Enantioselective synthesis of β-amino acids. 7. Preparation of enantiopure α-substituted β-amino acids from 1-benzoyl-2(S)-tert-butyl-3-methylperhydropyrimidin-4-one.1,2
✍ Scribed by Eusebio Juaristi; Delia Quintana; Margarita Balderas; Enrique García-Pérez
- Book ID
- 108036466
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 796 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
The title heterocycle is prepared in enantiomerically pure form and in 46-50% overall yield from (S)-asparagine, a readily available starting material. The synthetic route described in this report represents a major improvement over the original procedure (Tetrahedron: Asymmetry 1991, 3, 723), that
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We report here the synthesis of 3,7-disubstituted perhydro-1,4-diazepine-2,5-diones from amino acids and b-amino acids using a backbone amide linker (BAL) as a cis-configuration inductor. We have optimized each steps of the synthesis on solid support using Mimotopes crowns.