Enantioselective Synthesis of α-Quaternary Amino Acid Derivatives by Sequential Enzymatic Desymmetrization and Curtius Rearrangement of α,α-Disubstituted Malonate Diesters
✍ Scribed by Iosub, Violeta; Haberl, Anton R.; Leung, Jennifer; Tang, Michael; Vembaiyan, Kannan; Parvez, Masood; Back, Thomas G.
- Book ID
- 120479899
- Publisher
- American Chemical Society
- Year
- 2010
- Tongue
- English
- Weight
- 914 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
The sequential addition of two different nucleophiles to a tartaric acid-derived nitrile produced carbinamines. The adducts from chelation-controlled addition which are obtained in high diastereoselectivities and yields, were easily converted to ct,ct-disubstituted-t~-amino acids.
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