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Enantioselective synthesis of α-methyl carboxylic acids using a DiTOX chiral auxiliary

✍ Scribed by Philip C Bulman Page; Michael J McKenzie; Steven M Allin; Sukhbinder S Klair

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
999 KB
Volume
53
Category
Article
ISSN
0040-4020

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✦ Synopsis

Five 0~-methyl carboxylic acids have been prepared with high e.e.s using 1,3-dithiane 1 -oxide (DiTOX) units as the stereocontrolling elements and sources of chirality.

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Novel steroidal chiral auxiliaries: Enan
Novel steroidal chiral auxiliaries: Enantioselective synthesis of chiral α-hydroxy acids
✍ Deeng-Lih Huang; Richard W. Draper 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 161 KB

## The synthesis is reported of three novel steroidal chiral auxiliaries (4) which were used to generate an a-hydroxy acid in high optical parity (90-9896 cc). Chiral auxiliaries for enantioselective syntheses are of current interest13 Cyclohexyl based chiial auxiliaries, such as menthol, S-phenyl