Enantioselective synthesis of the C11–C17 segment of soraphen A1α via organoiron methodology

✍ Scribed by Yeyu Cao; Ahmad Farouk Eweas; William A Donaldson

• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 322 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01727-6

✦ Synopsis

The C11-C17 segment of the antifungal agent soraphen A 1a was prepared from glyceraldehyde acetonide in nine steps. The C12 stereocenter is derived from glyceraldehyde, while the C17 stereocenter as introduced by 1,6-asymmetric control via the coordinated Fe(CO) 3 .