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Enantioselective Synthesis of the Antidepressant Rolipram by Michael Addition to a Nitroolefin

✍ Scribed by Prof. Dr. Johann Mulzer; Dr. Ralf Zuhse; Dr. Ralph Schmiechen


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
382 KB
Volume
31
Category
Article
ISSN
0044-8249

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## Abstract A quinine‐promoted, enantioselective Michael addition reaction of diphenyl phosphite with nitroalkenes has been developed. This methodology affords a facile access to enantiomerically enriched β‐nitrophosphates, precursors for the preparation of synthetically and biologically useful β‐a