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Enantioselective Synthesis of the AB-Ring System of the Antitumor Antibiotic Tetrazomine

โœ Scribed by Wipf, Peter; Hopkins, Corey R.


Book ID
120267978
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
115 KB
Volume
66
Category
Article
ISSN
0022-3263

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A concise enantioselective synthesis of
โœ J.Stephen Clark; Robert J Townsend; Alexander J Blake; Simon J Teat; Amanda John ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 84 KB

The AB ring system found in the manzamine A and related alkaloids has been prepared from (-)-quinine by a short enantioselective route. The key step in the sequence is a ruthenium-catalysed ring-closing enyne metathesis re action which delivers a bicyclic diene in good yield. The functionality requi