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Enantioselective Synthesis of Spirocyclic Aminochroman Derivatives According to the CN(R,S) Strategy.

✍ Scribed by Gregoire Pave; Jean-Michel Leger; Christian Jarry; Marie-Claude Viaud-Massuard; Gerald Guillaumet


Publisher
John Wiley and Sons
Year
2003
Weight
116 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Abstract The diastereoselective synthesis of the __N__‐ and __O__‐protected hoprominol derivative (__R__,__R__,__R__)‐**6** is described. The building up of the bicyclic __O__‐silylated and di(__N__‐tosylated) asymmetric scaffold **6** succeeded by convergent preparation of the two basic chiral