Enantioselective synthesis of NK-1 receptor antagonists (+)-CP-99,994 and (+)-CP-122,721

✍ Scribed by Naoki Yamazaki; Masakazu Atobe; Chihiro Kibayashi

• Book ID: 104252083
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 255 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)01832-4

✦ Synopsis

An enantioselective total synthesis of NK-1 receptor antagonists, (+)-CP-99,994 and (+)-CP-122,721, is described. The key steps are diastereoselective addition of vinyllithium to a chiral benzaldehyde oxime ether and diastereoselective borane reduction of a cyclic oxime ether.