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Enantioselective synthesis of natural combretastatin

✍ Scribed by Alessio Ramacciotti; Rita Fiaschi; Elio Napolitano


Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
248 KB
Volume
7
Category
Article
ISSN
0957-4166

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## Abstract The naturally occurring Lycopodium alkaloid (+)‐luciduline (**1**) has been synthesized from (__R__)‐5‐methyl‐cyclohex‐2‐en‐1‐one (**12**) by a sequence of seven steps (s. __Scheme 6__) in 33% overall yield. The key step **4β†’6** presumably involves a transient nitrone **5** which underg