A convenient synthesis of 1-(S)-[1β²-(S)-
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Jonas BrΓ₯nalt; Ingemar KvarnstrΓΆm; BjΓΆrn Classon; Bertil Samuelsson; Ulrika Nill
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Article
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1997
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Elsevier Science
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French
β 206 KB
A new short route to epoxide 6b, a pivotal intermediate for the preparation of hydroxyethylamine dipeptide isosteres has been developed. Opening of the epoxide by anthranilic acid, followed by extensions in the P2/P3-region gave the target compounds which were evaluated as HIV-I protease inhibitors.