Enantioselective Synthesis of Cyclopentenones via Rhodium-Catalyzed Kinetic Resolution and Desymmetrization of 4-Alkynals.
β Scribed by Ken Tanaka; Gregory C. Fu
- Publisher
- John Wiley and Sons
- Year
- 2003
- Weight
- 190 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The Rhβcatalyzed asymmetric addition of Ξ±β (VII) or Ξ²βsubstituted Sβchelating aldehydes (I), (V) towards terminal alkynes (II) is successfully used as kinetic resolution procedure to afford the corresponding Ξ±β and Ξ²βsubstituted enones in up to 90% optical purity.