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Enantioselective synthesis of chiral benzylic amines. (A stereospecific transamination-alkylation reaction)

✍ Scribed by Arlette Solladie-Cavallo; Dariouch Farchani


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
250 KB
Volume
27
Category
Article
ISSN
0040-4039

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Stereospecific synthesis of chiral terti
✍ Yao-Jun Shi; David L. Hughes; James M. McNamara πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 124 KB

Mitsunobu reaction of chiral tertiary alcohol (S)-2 with phenol 3 provides the desired ether (R)-1 in moderate yields at elevated temperatures (80-100Β°C). The S N 2 displacement pathway is evident by complete inversion of the (S)-alcohol to (R)-ether.