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Enantioselective Synthesis of anti -β-Substituted γ,δ-Unsaturated Amino Acids: A Highly Selective Asymmetric Thio-Claisen Rearrangement

✍ Scribed by Liu, Zhihua; Qu, Hongchang; Gu, Xuyuan; Min, Byoung J.; Nyberg, Joel; Hruby, Victor J.


Book ID
127336428
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
312 KB
Volume
10
Category
Article
ISSN
1523-7060

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A significantly improved thio-Claisen rearrangement method was developed for preparing anti-b-functionalized c,d-unsaturated amino acids, which are extremely useful nonproteinogenic amino acids used in chemistry and biology research. The mild reaction condition successfully introduced base labile fu