Enantioselective synthesis of α-sulfenyl
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Dieter Enders; Thomas Schäfer; Wolfgang Mies
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Article
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1998
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Elsevier Science
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French
⚖ 776 KB
Asymmetric ot-sulfenylation of lithiated SAMP/RAMP hydrazoncs (3")-2 with disulfides afforded tz-thiolated hydrazones (S,R)-3 in good yields (48-87%) and high diastcreomeric excesses (91-96%). Subsequent oxidative cleavage or acidic hydrolysis of the hydrazones furnished a-thiolated ketones (R)-4a.d