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Enantioselective synthesis of 11-hydroxy-(1′S,2′R)-dimethylheptyl-Δ8-THC, a very potent CB1 agonist

✍ Scribed by John Liddle; John W Huffman

Book ID
108371328
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
120 KB
Volume
57
Category
Article
ISSN
0040-4020

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## Abstract The title compounds were synthesised in 7 steps from 1,7‐dihydroxynaphthalene as follows: 1,7‐dihydroxynaphthalene was methylated and subjected to a Birch reduction to yield 8‐methoxy‐2‐tetralone. Reductive amination with sodium cyanoboro[^3^H]hydride and n‐propylamine gave 8‐methoxy‐2‐