Enantioselective synthesis of 1-arylethanediols by rhodium-catalyzed transfer hydrogenation of α-tosyloxyarylketones
✍ Scribed by Do-Min Lee; Gullapalli Kumaraswamy; Kee-In Lee
- Book ID
- 106214071
- Publisher
- Springer Vienna
- Year
- 2008
- Tongue
- English
- Weight
- 190 KB
- Volume
- 140
- Category
- Article
- ISSN
- 0026-9247
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract The reaction applies a HCOOH/NEt~3~ mixture as a hydrogen source and a chiral Rh‐complex as a catalyst.
The highly enantioselective synthesis of 2,2-difluoro-3-hydroxycarboxylates has been achieved by hydrogenating 2,2-difluoro-3-oxocarboxylates in the presence of chiral rhodium-(amidephosphine-phosphinite) complexes. Ethyl 4,4,4-trifluoroacetoacetate can be successfully transformed into the enantiome
The enantioselective hydrogenation of ethyl pyruvate in the presence of TS-1 supported rhodium nanoclusters and chiral modifier cinchonidine, cinchonine and quinine was investigated. The results showed that cinchonidine was the best modifier and THF was an excellent solvent for the reaction. Cinchon