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Enantioselective syntheses of 3-substituted 4-(alkoxycarbonyl)-2-azetidinones from malic acid

✍ Scribed by Miller, Marvin J.; Bajwa, Joginder S.; Mattingly, Phillip G.; Peterson, Kathleen


Book ID
121227027
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
819 KB
Volume
47
Category
Article
ISSN
0022-3263

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Synthesis of substituted 3-hydroxy-4-alk
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A short chemical process is described for the synthesis of optically active 3y roxy-4-alkoxycarbonyl-Z-azetidinones (R-lactams) from L-tartaric acid. Tartaric acid is an extremely useful and versatile member of the chiral pool. Since nearly any type of f+hydroxy acid can be converted to a 8-lactam (