A series of 12 chiral arylcarboxylic acids were chromatographed on an immobilized human serum albumin chiral stationary phase (HSA-CSP). The effects of solute structure on chromatographic retentions and enantioselective separations were examined by linear regression analysis and the construction of
Enantioselective separation of thalidomide on an immobilized α1-acid glycoprotein chiral stationary phaseglycoprotein chiral stationary phase
✍ Scribed by C. Álvarez; J. A. Sánchez-Brunete; S. Torrado-Santiago; R. Cadórniga; J. J. Torrado
- Book ID
- 110550175
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 354 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0009-5893
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A binding study on ␣ 1 -acid glycoprotein (AGP), a widely used chiral stationary phase in drug analysis, has been performed. Being a selectivity decisive factor in enantiomer separation, the adsorption of the organic modifiers, as the regularly used acetonitrile (AcCN) and also of dioxane, was deter
## Abstract The binding and chiral separation of __R__‐ and __S__‐propranolol was investigated on a new type of α~1~‐acid glycoprotein (AGP) column. This column was prepared through the controlled and mild oxidation of AGP, followed by the immobilization of this protein to hydrazide‐activated silic