Enantioselective Reductive Amination of α-Keto Acids to α-Amino Acids by a Pyridoxamine Cofactor in a Protein Cavity
✍ Scribed by Kuang, Hao; Brown, Matthew L.; Davies, Ronald R.; Young, Eva C.; Distefano, Mark D.
- Book ID
- 118024344
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 282 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
The sequential addition of two different nucleophiles to a tartaric acid-derived nitrile produced carbinamines. The adducts from chelation-controlled addition which are obtained in high diastereoselectivities and yields, were easily converted to ct,ct-disubstituted-t~-amino acids.
The inversion of configuration of L-alanine can be carried out by combining its selective oxidation in the presence of NAD + and L-alanine dehydrogenase, electrochemical regeneration of the NAD + at a carbon felt anode, and reductive amination of pyruvate, i.e., reduction of its imino derivative at
Section I. Microbiological Techniques -- Section Ii. Alanine -- Section Iii. Delta-aminolevulinic Acid -- Section Iv. Arginine And Ornithine -- Section V. Aromatic Amino Acids -- Section Vi. Aspartic Acid And Asparagine -- Section Vii. Branched-chain Amino Acids (leucine, Isoleucine, And Valine) --