Enantioselective PhSe-Group-Transfer Tandem Radical Cyclization Reactions Catalyzed by a Chiral Lewis Acid

✍ Scribed by Dan Yang; Bao-Fu Zheng; Qiang Gao; Shen Gu; Nian-Yong Zhu

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 155 KB
• Volume: 118
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/ange.200503056

✦ Synopsis

Tandem radical cyclization, which is a powerful method for the synthesis of polycyclic compounds, is used widely in the syntheses of natural products. [1] Only a few asymmetric tandem radical cyclization reactions are known, [2, 3a] however, and no enantioselective group-transfer radical reactions have been reported. [4] Herein we report a catalytic enantioselective group-transfer radical cyclization reaction and its applications in tandem reactions.