Enantioselective phenylacetylene addition to aldehydes induced by Cinchona alkaloids

✍ Scribed by Rajesh M. Kamble; Vinod K. Singh

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 131 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01196-1

✦ Synopsis

Enantioselective addition of phenylacetylene to various aldehydes was studied in the presence of inexpensive and commercially available Cinchona alkaloids. A maximum of 85% ee was obtained using cinchonidine in the presence of Ti(O i Pr) 4 .