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Enantioselective phase-transfer catalytic α-alkylation of 2-methylbenzyl tert-butyl malonates

✍ Scribed by Ha, Min Woo; Hong, Suckchang; Park, Cheonhyoung; Park, Yohan; Lee, Jihye; Kim, Mi-hyun; Lee, Jihoon; Park, Hyeung-geun


Book ID
120372597
Publisher
Royal Society of Chemistry
Year
2013
Tongue
English
Weight
321 KB
Volume
11
Category
Article
ISSN
1477-0520

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Facile asymmetric synthesis of L-Dopa and related amino acid esters has been achieved by phase-transfer catalysis of the rationally designed C 2 -symmetric chiral quaternary ammonium salts 1. The 'scale-up' experiment performed with 5.00 g of tert-butyl glycinate-benzophenone Schiff base (2) represe