Enantioselective palladium catalyzed allylic alkylation with phosphorus-containing C2-symmetric chiral amine ligands

✍ Scribed by Hideki Kubota; Kenji Koga

• Publisher: Elsevier Science
• Year: 1994
• Tongue: French
• Weight: 253 KB
• Volume: 35
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)73469-1

✦ Synopsis

In the presence of the palladium complex with the phosphorns-containing Q-symmetric chiral amine ligand 2.3. the asymmetric allylic substitution of racemic 1,3_diphenyl-2-propenyl acetate 8 with dimethyl tnalonate proceeded in high yield with mm&able enaotiometic excess. Enantioselective palladium catalyzed allylic alkylation has been exploited with a variety of chiral ligands. 1 Recently, chiral nitrogen ligands have received a great deal of attention.? Although the chiral nitrogen ligands