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Enantioselective oxidation of prochiral 2-methyl-1,3-propandiol by Acetobacter pasteurianus

✍ Scribed by Francesco Molinari; Raffaella Gandolfi; Raffaella Villa; Eva Urban; Andreas Kiener

Publisher: Elsevier Science
Year: 2003
Tongue: English
Weight: 124 KB
Volume: 14
Category: Article
ISSN: 0957-4166
DOI: 10.1016/s0957-4166(03)00407-5

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✦ Synopsis

The microbial oxidation of prochiral 2-methyl-1,3-propandiol into (R)-3-hydroxy-2-methyl propionic acid with Acetobacter pasteurianus DSM 8937 is reported. The biotransformation was optimised furnishing (R)-3-hydroxy-2-methyl propionic acid with 97% enantiomeric excess and 100% molar conversion of 5 g/L within 2 h. A simple fed-batch procedure allowed for the obtainment of 25 g/L of the enantiomerically enriched acid. (R)-3-Hydroxy-2-methyl propionic acid is an important building block for the synthesis of Captopril, a widely used antihypertensive drug.

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