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Enantioselective hydrogenation of ethyl pyruvate catalyzed by polyvinylpyrrolidone-stabilized and supported rhodium nanocluster

✍ Scribed by Yulin Huang; Yaozhong Li; Jiayuan Hu; Puming Cheng; Hua Chen; Ruixiang Li; Xianjun Li; C.W. Yip; Albert S.C. Chan

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
94 KB
Volume
189
Category
Article
ISSN
1381-1169

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✦ Synopsis

The enantioselective hydrogenation of ethyl pyruvate catalyzed by finely dispersed oxide supported rhodium nanocluster was studied with cinchonidine as chiral modifier. The results indicated that cinchonidine not only exhibited good enantiodifferentiating ability but also could accelerate the reaction by a factor 10. Supports (β₯-Al 2 O 3 , SiO 2 , TiO 2 ) played an important role in promoting the further increase of catalytic activity and enantioselectivity of polyvinylpyrrolidone-stabilized rhodium nanoclusters (Rh/PVP). Under the optimum reaction conditions (298 K, 7.0 MPa of hydrogen pressure and tetrahydrofuran as solvent), TOF and the enantiomeric excess reached 58.6 min -1 and 65.4% e.e., respectively.

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